NOVA: a software to analyse complexome profiling data

NOVA is a program designed to analysis complexome profiling data (Heide et al., 2012). A graphical user interface (GUI) provides various visualization tools, such as heat maps and 2D plots. Several hierarchical clustering algorithms (e.g., single linkage, average linkage, Wards linkage), different distance measures (e.g., Euclidean distance, Manhattan distance, Pearson distance), and various normalization techniques are implemented. Many additional functions like zooming, searching for proteins, image export, and automatic file format recognition support intuitive handling for biologists.

NOVA is developed in cooperation with the Molecular Bioenergetics Group at the Medical School of the Goethe-University in Frankfurt. The group which was led by Ulrich Brandt introduced the complexome profiling method (Heide et al., 2012).

H. Heide, L. Bleier, M. Steger, J. Ackermann, S. Dröse, B. Schwamb, M. Zörnig, A. S. Reichert, I. Koch, I. Wittig, and U. Brandt. Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex. Cell Metabolism, 16:538–549, 2012.